Side effects: You may experience different side effects as the medications work through slightly different pathways: Nausea and digestive symptoms may temporarily increase or change Some people report less fatigue with Wegovy compared to Mounjaro Headaches sometimes occur during the transition, but typically resolve Weight: Your weight may fluctuate slightly during the transition
These data are supported by a recent meta-analysis of 17 trials that included 2,851 patients: the study concluded that cryotherapy reduced the incidence of CIPN and improved quality of life for cancer patients (Tai 2024)
Whilst these in vitro results could potentially represent an artefact of the co-cultures employed, we showed that functional ATP-dependent cross-talk with afferent nerves is also observed in an acute ex vivo colonic preparation
Aoyama E, Watari I, Podyma-Inoue KA, Yanagishita M, Ono T (2014) Expression of glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells
Changes in sexual function may relate to rapid weight loss, metabolic shifts, gastrointestinal side effects, or psychological factors rather than the medication itself
8 Concerningly, lifestyle improvements are often difficult to sustain, underscoring the potential benefits of early initiation and background therapy with GLP-1RA due to its benefits on metabolic disorders (Table 3) and chronic liver disease
