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GIP enhances insulin secretion and plays a role in lipid metabolism

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The animal literature is unusually consistent, though: nearly every published in vivo study used 5 mg/kg per injection, given three times on alternate days (days 1, 3, and 5, or days 14, 16, and 18 in the pulmonary fibrosis model), with effects tracked over the following three to four weeks

It also activates transcription of apoptosis-related genes like p21/Cip1, leading to G1-phase cell cycle arrest [186, 187]

Inflammation, congestion, or damage to the nasal mucosa can impair peptide uptake