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These drugs by increasing insulin secretion and possibly, beta cell mass, decrease plasma glucose and lipids and have a secondary action to reduce food intake and bring about weight loss
Nonetheless, comprehensive real-world economic assessments across various healthcare systems are few, highlighting a significant research need for informed policy choices about coverage and accessibility
This low initial dose is a tolerability phase, as it allows the body to adjust to GLP-1 signaling and reduces the risk of nausea and other gastrointestinal side effects before doses are increased
*Compounded medications are not evaluated by the FDA for safety or efficacy
Allergic reactions to semaglutide, though rare, can occasionally present with injection site manifestations beyond simple bruising
The dose stays low
