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The Phase 2 trial (Jastreboff et al., NEJM, 2023) used the same route
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The skin may be thinner, the distribution of the residual fat may be less predictable, and areas of fibrous tissue from prior fat deposits may need particular procedures to be treated well
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Importantly, a prespecified exploratory analysis of the AMPLITUDE-O trial found comparable benefits of GLP-1 RA treatment in participants who were receiving an SGLT2i as background therapy (15% of the total trial population) and those who were not [241]
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