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Better movement and faster recovery follow as the weeks progress

Start at the lowest effective dose and escalate every 4 weeks only if the current dose is well tolerated

J Hum Genet 60, 657664 (2015)

doi: 10.3389/fphar.2025.1737199 Received 01 November 2025 Revised 21 December 2025 Accepted 29 December 2025 Published 15 January 2026 Volume 16 - 2025 Edited by Dawei Chen, University of Kiel, Germany Reviewed by Eveljn Scarian, University of Pavia, Italy Hong Cheng, Yangzhou University, China Updates Copyright 2026 Knudsen, Tadje, Coggins and Venketaraman

Genetic insights may help explain individual differences in appetite suppression, weight-loss trajectory, or side-effect sensitivity, but do not predict whether NAD supplementation will enhance outcomes

A method of treating sexual dysfunction in a patient marginally responsive to a PDE- 5 inhibitor, comprising: establishing a dose of a PDE-5 inhibitor to which the patient is marginally responsive