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Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: A phase 2, randomized, placebo-controlled, dose-escalation study
Escalation phase breakdown The standard protocol starts low and increases every four weeks to minimize gastrointestinal side effects that rapid dose escalation can cause
In the SELECT trial, patients did not enroll for the specific purpose of weight loss and received standard of care covering management of CV risk factors, including medical treatment and healthy lifestyle counseling, but without a specific focus on weight loss
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