Type 2 deiodinase (DIO2), expressed in astrocytes and tanycytes, converts T4 to active T3, ensuring a sufficient local hormone supply despite systemic variation (57, 58)
That said, the combination itself has not been clinically validated there are no controlled human trials of this specific blend, and the supporting data for each peptide is largely preclinical (animal) work and anecdote
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PLoS One 4 , e8131 (2009)
Preliminary identification can be done through simple sensory inspection