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Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism

Additionally, significant liver impairment is another contraindication ( Metformin can be used safely in youth with elevated liver enzymes in the context of NAFLD, provided liver function is preserved (165167)

Moderate changes of the K m app values in combination with the altered k cat app values resulted in decreased apparent catalytic efficiencies of E170A/K for both substrates as compared with the wild-type enzyme and E170D (Fig

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