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Eur Thyroid J 5:926 Jonklaas J, Bianco AC, Bauer AJ et al (2014) Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement

Increase to 0.5 mg Weekly After Initial Tolerance Develops Once the initial four weeks are completed and tolerance is established, the dose is increased to 0.5 mg weekly

Beyond weight, the glucagon receptor agonism component carries theoretical benefits for non-alcoholic fatty liver disease (NAFLD), now reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD)

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In topical application, studies use concentrations of 0.01-1% in cream or serum formulations (Pickart et al., BioMed Res Int 2015For subcutaneous injection (research), doses vary depending on the experimental model