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Dysbiosis, or an imbalance in gut microbiota, is associated with metabolic diseases, especially T2DM, and can cause changes in the signaling pathways of intestinal hormone secretion, leading to various health problems [156]

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The regulatory mechanism of glutamine in the TME Glutamine relies on transporters to enter tumor cells Glutamine is hydrophilic and must pass through certain selective transporters to enter the interior of tumor cells [35]

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Cangfu Daotan Decoction can reduce the levels of total cholesterol (TCHO), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), luteinizing hormone, and testosterone in the serum of PCOS rats, and increase the levels of high-density lipoprotein cholesterol (HDL-c), follicle-stimulating hormone, and estradiol in a dose-dependent manner (47)

doi:10.1021/acs.jmedchem.5b00726 Hay DL, et al