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Providers frequently prescribe Ozempic for weight loss for people without type 2 diabetes, this is an off-label use and isnt a common practice with metformin

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The SURMOUNT-1 trial (Jastreboff et al., NEJM 2022) is the landmark efficacy data: tirzepatide at 15mg weekly produced 22.5% average body weight reduction over 72 weeks in adults with obesity without diabetes the highest weight reduction ever documented in a pharmaceutical trial