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Additionally, MEGA-PRESS GSH quantification presents inherent methodological challenges: the relatively long TE (79 ms) required for J-difference editing results in T-weighted signal attenuation, and the low concentration of GSH (~ 12 mM) combined with spectral overlap necessitates careful interpretation of absolute values

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Therefore, microsphere sustained-release technology is being utilized to enable GLP-1 drugs to be released slowly and continuously, or GLP-1 molecules are being modified and optimized through structural modifications to develop GLP-1 RAs with longer half-lives

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