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OXIDATION TOXIC PATHWAY (CYP2E1 enzyme) Only 5-10% of acetaminophen in healthy non-pregnant adults INCREASES by 80% during pregnancy[] Creates NAPQI (N-acetyl-p-benzoquinone imine)the toxic metabolite NAPQI formation 43% HIGHER in first trimester[] NAPQI must be immediately neutralized by glutathione When glutathione is depleted, NAPQI causes cellular damage Crosses the placenta and damages fetal brain HOW PREGNANCY CHANGES ACETAMINOPHEN METABOLISM METABOLIC PATHWAY CHANGES DURING PREGNANCY[] Human pharmacokinetic studies reveal dramatic shifts in how pregnant women metabolize acetaminophen: Oxidation to NAPQI (Toxic Pathway) INCREASES by 80% The Brookhuis et al

Kynurenic acid as an antagonist of 7 nicotinic acetylcholine receptors in the brain: facts and challenges

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Therefore, it is more beneficial to consume these foods raw or lightly steamed if possible

Herrmann W et al., Osteoporos Int 2009 B12, homocysteine, and bone health

Nuzzo adds that increased energy and faster muscle recovery often kick in within the first month of supplementation