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Energy Levels: How Does Semaglutide Make You Feel
It's produced from a larger precursor protein (proglucagon) inside enteroendocrine L-cells, which are most concentrated in the distal small intestine and colon
Tirzepatide, the drug in Mounjaro, is a peptide with a molecular weight too high to be absorbed through the gut wall, even with the kind of absorption enhancer used to make oral semaglutide work
Gastroenterology 144 , 12521261 (2013)