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The remodelling of TME can be achieved by either decreasing the matrix barrier or enhancing the immunosuppressive microenvironment, concentrating on the gut microbiota and metabolites, and modifying immune cells and cytokines (58, 59)

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide[J].Journal of Medicinal Chemistry, 2015, 58(18):7370.DOI:10.1021/acs.jmedchem.5b00726

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Future models might show more savings as evidence accumulates of additional medical benefits from these medications

Carr, Margreet C