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Clinical trials have shown that rapidly improving blood sugar levels can worsen the existing eye damage in some patients

[52] Clinical trials shown that GLP-1 receptor agonists improve menstrual regularity , decrease body weight and central adiposity, increase sex hormone-binding globulin levels , and lower free testosterone in overweight and obese women with PCOS

This happens more often than people admit

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Open any study for a plain summary, what it measured, the finding, and a link to the paper