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Topline Eli Lilly, the GLP-1 maker behind Mounjaro and Zepbound, said it would file for Food and Drug Administration approval of its powerful retatrutide weight-loss drug after studies found participants lost an average of nearly 56 pounds after 80 weeks on the medication

For researchers concerned about muscle preservation during weight loss, several strategies can help regardless of which treatment is chosen

The whitening maintenance time cannot be permanent

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Choose a medication, then switch between the month-to-month and five-year views to see how the total adds up over time