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However, its efficacy is substantially compromised in patients with obesity caused by MC4R deficiency, a common monogenic form of obesity

Add MOTS-c at Week 5 once tolerance is set

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Given the impact of androgen excess on multiple reproductive and metabolic parameters of females, such analyses are deemed mandatory in order to define the potential utility of such compounds for the personalized treatment of women suffering from PCOS

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Discuss these changes with your partner and healthcare provider if you notice them