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Its potential benefits stem from its role in intracellular signaling pathways that influence insulin sensitivity and ovarian function mechanisms that underlie many of the outcomes studied in clinical research.7 12 15 17 Although inositol is often associated with PCOS, much of the research points to metabolic signaling as the common thread, with reproductive and fertility-related benefits often building on those effects
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Therefore, if an inducer of CYP2C8 is started or stopped during treatment with alogliptin and pioglitazone tablets, changes in diabetes treatment may be needed based on clinical response without exceeding the maximum recommended daily dose of alogliptin and pioglitazone tablets (25 mg of alogliptin and 45 mg of pioglitazone) [see Clinical Pharmacology (12.3)]
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