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Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells

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Adding keto to this pair can produce excellent blood sugar control and weight loss, but it also increases the risk of lactic acidosis (rare but serious with metformin) and hypoglycemia (low blood sugar) because three separate mechanisms are all working to lower blood glucose simultaneously

No amount of waiting for 'full clearance' changes that timeline, because the melanin was synthesised days earlier when the peptide was still active