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It is not recommended for individuals with known allergies to its components, or for those with chronic asthma, unless approved by a physician

In their separate trials, retatrutides top dose produced an average weight loss of 28.3%, compared with 20.7% for Wegovy 7.2 mg in STEP UP

A clinically significant interaction exists between tirzepatide and oral contraceptives, requiring backup contraception for 4 weeks after initiation and each dose increase, and patients taking levothyroxine or other time-sensitive medications warrant closer monitoring

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After all necessary data was collected for the Morris water maze test, the mice were euthanized and the brain tissue was dissected