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Rodent studies have shown that treatment with liraglutide or once-weekly exenatide is associated with thyroid C-cell proliferation and the formation of thyroid C-cell tumors (11, 63)

Helminths are known to possess ABC/MDR transporters, P-glycoprotein, and other efflux transporters that mediate the transport of molecules and antimicrobials across the membrane modulating drug susceptibility 55

A recent review explored potential triggers for such treatment decisions and identified many factors, ranging from treatment effectiveness and side effects to changes in pharmacy benefit coverage and patient preference [11]

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