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This review has highlighted how mitochondrial-immune crosstalk is a unifying paradigm explaining much of perioperative organ dysfunction, from sterile inflammation in the heart and brain to delayed healing and infection susceptibility

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222 GPX4 is one of the main antioxidant protective enzymes in pancreatic cells and plays an important role in reducing lipid peroxides and protecting cells from ferroptosis in T2DM

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This is the same mechanism targeted by topical brightening agents, delivered systemically instead, and the effect is best understood as a gradual, cumulative brightening support across a series rather than an overnight change

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