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A 2017 survey showed concentrations up to 10% are used in rinse-off cleansers and roughly 0.5-5% being typical in skincare

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This effect might be explained that targeted nanocarriers help the internalization of ibuprofen and its anti-inflammatory action in brain endothelial cells

doi: 10.1172/JCI44490 69 MehtaVPeiWYangGLiSSwamyEBosterAet al