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Furthermore, facilitative-carriers, which are sodium-independent, are located either in the luminal side or in both luminal and abluminal membranes (see Tables 1 and 2 for names, substrates and location of each transporter)

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The rats were anesthetized with intraperitoneal injection of pentobarbital sodium (50 mg/kg), and dorsal hair was shaved and depilated with hair removal cream

Consistent with this notion, animal models have shown spread of HSV-1 from the nasal cavity to the CNS after infection of the olfactory epithelium, which is connected with the olfactory bulb and consequently the limbic system, resulting in focal encephalitis in the brain (Figure 1A