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Further characterization of the human commensals capable of both reactions (l-carnitineBB and BBTMA), and discovery of the enzyme(s) responsible for TMA production, are of interest particularly since this latter microbial step in the overall pathway appears to be the major one induced during chronic dietary red meat exposure (or directly with l-carnitine supplementation) in an omnivorous diet (Figure 10)

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Route of administration PT-141, like most therapeutic peptides, can be administered via subcutaneous injection, but its also available as an intranasal spray

Subsequently, macrophages transform into foam cells in the LDL cholesterol-deposited vascular endothelium

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