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In humans, its mostly produced by the liver

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92 Phosphorylation and activation of AMPK is in response to nutrients and AMP/ATP ratio through the upstream kinases serine/threonine kinase (LKB1) and calcium/calmodulin-dependent protein kinase (CaMKK)

[12] These findings do not establish efficacy for muscle growth, fat loss, anti-aging, sleep improvement, bone-density treatment, or any other personal-use application