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The media frenzy over these so-called "weight loss drugs" has also resulted in pharmaceutical companies tightening restrictions on who is able to access the medications, leading to rejections of valid prescriptions, delays in treatment, and other issues
This may cause severe and intolerable side effects
Incretins, such as GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), are secreted by entero-endocrine cells of the gastrointestinal tract to stimulate glucose-dependent insulin secretion and beta-cell proliferation
Mechanism: This effect is mediated by the activation of the vagus nerve and direct effects on gastric smooth muscle (Zheng et al., 2024)
2-month minimum commitment and higher-dose pricing increases are not clearly mentioned before intake
Rajkumar R, et al
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