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These include: Patients with high cholesterol or dyslipidemia, which affects blood flow to the optic nerve Those with hypertension, putting additional strain on the blood vessels in the eyes Individuals with diabetes mellitus, especially those with existing diabetic retinopathy Patients with a history of sleep apnea, which has been independently linked to NAION development Ocular Conditions Existing eye conditions significantly increase the risk profile

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AP resident Glp1r -expressing neurons (Casr_Glu) showed the strongest response to semaglutide treatment, consistent with our previous findings 41 (Fig