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The UK medicines regulator, the MHRA, has updated the product information for healthcare professionals and patients regarding the "small risk of severe acute pancreatitis in patients taking GLP-1s." While rare, the sheer scale of GLP-1 use in the UK with one recent study suggesting 1.6 million adults had used them in the last 12 months, and 3.3 million were interested in trying them in the following year makes it important for clinicians and patients to be aware of the warning signs of pancreatitis, said the regulator

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GLP1 alone significantly reduced body weight and fat mass, and improved glucose handling, as well as serum glucose and insulin concentrations, and insulin sensitivity in this PCOS model (Fig

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