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Preclinical and phase I clinical trial data for a triple GLP1GIPglucagon receptor co-agonist therapy (LY3437943) suggest that it is effective at inducing weight loss, without inducing adverse effects that would require discontinuation

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Such guidelines would help researchers find optimal dosages based on research objectives, desired outcomes, and the characteristics of the experiment

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Because of lack of renal clearance, serum values rose to more than a hundredfold from 422 pmol/L on average to 54 000 pmol/L, with 67 000 pmol/L as highest value, without side-effects