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Lifestyle modifications, including regular moderate exercise, proper hydration, and limiting alcohol and tobacco use, are equally important

Metabolic rate does decrease as weight drops, which is a normal physiological response

ClinicalTrials.gov is the authoritative place to check if that ever changes

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Preliminary results from a late-stage trial involving adults with obesity and knee osteoarthritis showed average weight loss of about 28.7% after 68 weeks, suggesting the drug may be even more effective than earlier treatments