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Of the ZEPBOUND-treated patients in OSA clinical studies, 37.2% and 19.5% of patients developed antibodies that were cross reactive to native GIP and native GLP-1, respectively
Another in vivo study found that in vivo knockdown of the TCF7L2 gene in mouse adipocytes resulted in impaired glucose tolerance and reduced GLP-1 levels (Nguyen-Tu et al., 2020)
Severe gastrointestinal disease may worsen with incretin therapy
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The cell-internalized radioisotope activities per incubated probe activities after 120 min of incubation were significantly higher than those after 30 min of incubation in both cell lines (INS-1 cells: 0.060 0.003 vs
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