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Phase 2 data published in the New England Journal of Medicine (Jastreboff et al., 2023) showed average weight reductions of up to approximately 24% over 48 weeks at the highest doses studied, primarily in adults without type 2 diabetes

Do not use loperamide preventively or daily

they are a catalyst

While ingredients like green tea extract or caffeine may sound promising, theres little proof they lead to meaningful or lasting weight loss

Obesity, insulin resistance and fatty liver may further amplify this cycle by increasing inflammatory signaling, altering bile-acid metabolism and reducing metabolic reserve

Abdominal distension with rigidity or tenderness