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12, 13 Activated MCs rapidly release granules containing preformed mediators such as the vasoactive amine, histamine

Moreover, this study also raises awareness of the risks of gastrointestinal adverse events induced by GLP-1RAs, and safety concern is especially warranted for high dose administration

Fralick, M., Chen, S

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Phloretin suppresses carbohydrate-induced GLP-1 secretion via inhibiting short chain fatty acid release from gut microbiome