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Because tirzepatide does not raise insulin levels when blood sugar is low, it has a lower risk of causing low blood sugar (hypoglycemia) compared to some older diabetes drugs like sulfonylureas or insulin

It can be substituted for choline, which aids in reducing liver fat and detoxifies amines, which are by-products of protein metabolism

Sanofi Position: Has historically worked in the GLP-1 space (with drugs like liraglutide, lixisenatide) and is now focusing on metabolic disease innovation and new partnerships

Two main transport pathways occur within BBB: transcellular via endothelial used by the vast majority of the molecules which can be active (dependent on energy) or passive

These results are consistent with the absence of observed differences in MACE risk associated with exenatide in the EXSCEL trial,14 contrasting with the beneficial outcomes seen with liraglutide and semaglutide

Recent studies show how polyphenols and other bioactive compounds could improve the vascular health and metabolic outcomes of T2DM patients