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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

Available from: books/NBK519513/ [26] Benvenga S, Feldt-Rasmussen U, Bonofiglio D, et al

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