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DSIP Reported Research-Context Dose Ranges Pattern Older human trials Typical Range 25 nmol/kg Route IV Notes Short 4-7 night courses

The genes exemplified in Figure 4 comprise markers of inflammation and plaque stability that are associated with leukocyte recruitment (e.g., IL-1RN, IL-6, CCL2, OPN), leukocyte adhesion (SELE, VCAM-1), leukocyte extravasation, and plaque stability (e.g., MMP-3, MMP-13, CCL2), and plaque rupture and hemorrhage (CD163)