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Tirzepatide alone achieves 20.9% loss in SURMOUNT-1, which exceeds what most semaglutide-bupropion combinations achieve in observational data

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It also helps with weight management in people with obesity and overweight

doi: 10.1038/s42255-024-01061-4 40 KillionEAChenMFalseyJRSivitsGHagerTAtanganLet al

1 Introduction The advent of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their combinations, as pharmacological treatments for obesity and type 2 diabetes, has sparked intense debate about their role relative to traditional lifestyle interventions such as exercise and dietary modification