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The clinical efficacy of infusions for many specific indications, on the other hand, is still under investigation
doi: 10.1172/JCI69600 16 van GeldermalsenMWangQNagarajahRMarshallADThoengAGaoDet al
Molecular characterization advanced significantly in the 1980 s and 1990 s, highlighted by the identification of zonula occludens-1 (ZO-1) in 1986 as the first scaffolding TJ protein, and occludin in 1993 as the first transmembrane TJ protein associated with barrier function [16]
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