Vandeputte, P., Ferrari, S
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Animal toxicology studies and the limited human observations suggest BPC-157 is generally well-tolerated in the short term
Science 362 , 10641069 (2018)
The original 2015 Cell Metabolism study demonstrated that intraperitoneal MOTS-c injections (5 mg/kg) in mice fed a high-fat diet prevented obesity and insulin resistance, with effects on fat mass, fasting glucose, and insulin sensitivity that rivaled pharmaceutical intervention [1]
The FH domain is surrounded by large N- and C-terminal intrinsically disordered regions which are essential for the regulation of FOXO function