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For moderate to severe RLS that significantly impacts quality of life, UK guidelines suggest dopamine agonists (such as pramipexole, ropinirole, or rotigotine) or gabapentinoids (gabapentin or pregabalin) may be considered as first-line pharmacological treatments under specialist guidance

[81] [82] In 2004, he appeared in three films: The Coen brothers' The Ladykillers , Spielberg's The Terminal and Zemeckis's The Polar Express , a family film for which Hanks played multiple motion capture roles

The logic follows that if telomerase extends cell lifespan, it might also promote cancer development

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