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The full mechanistic picture remains an active area of research

Zepbound raked in $4.3 billion in the fourth quarter, which was up 123% year over year and an increase from $3.6 billion in the third quarter and, Yee noted, the drug continues to show robust growth despite compounded injectable GLP-1 Wegovy. Lilly is projecting 2026 sales to come in at between $80 billion and $83 billion, Fierce Pharma reported this week

CrossRef Senescent fibroblasts drive CD8+ T cell dysfunction in colorectal cancer via CD36-mediated lipid transfer and peroxidation Mengxiao Ge, Shuangyi Sun, Wentong Chen, Zhenxiao Xu, Deyi Kang, Zeqin Wang, Yumeng Guo Journal of Translational Medicine .2026;[Epub] CrossRef Adjuvant cytokine-induced killer cell immunotherapy in hepatocellular carcinoma: real-world data and 9-year extended follow-up of a randomized controlled trial Hyunjae Shin, Youngsu Park, Byeong Geun Song, Won-Mook Choi, Hyung Joon Han, Youngwoo Lee, Tae-Jin Song, Jong-Eun Yeon, Young-Suk Lim, Moon Haeng Hur, Yun Bin Lee, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Joon Hyeok Lee, Jung-Hwan Yoon, Jeong-Hoon Lee Cancer Immunology, Immunotherapy .2026;[Epub] CrossRef Dietary lipids synergistically enhance PAH bioavailability and intestinal toxicity: Mechanistic insights from a Caco-2 model Xiaofang Liu, Jie Zhu, Wanyi Zou, Li Liang, Jixian Zhang, Chaoting Wen, Youdong Li, Guoyan Liu, Xin Xu Food Bioscience .2026

Adapted from Vniant, M.M

In the phase 2 retatrutide obesity trial, the highest studied group had a mean weight reduction of 17.5% at 24 weeks and 24.2% at 48 weeks

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