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These can include nausea, constipation, diarrhea, reflux, bloating, decreased appetite, abdominal discomfort, or vomiting
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Some patients feel tired during early dose adjustment
Genetic variation in GLP-1 receptor (GLP1R), glucagon-dependent insulinotropic polypeptide receptor (GIPR), and melanocortin-4 receptor (MC4R) pathways may influence individual metabolic response and side-effect tolerance
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Diabetic rats treated for 42 d with a daily dose of 300 mg/kg of porcine skin gelatin showed their plasma glucose AUC reduced from 30 000 to 28 000 mg min/dl (1665 to 1554 mmol min/l), insulin levels increased 2-fold, active GLP-1 levels reduced from 15 to 135 pm and DPP4 activity reduced by half (Reference Huang, Hung and Jao48)
