obesity drug news today october 2025 glp-1 9 trends 2025: real-world data, patient outcomes & future therapies Weight Reduction with GLP-1 Agonists – Oral Obesity Drug Battle Is

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Moving forward, the results of the phase 3 SURPASS clinical trial program demonstrated that tirzepatide was as effective and safe as other anti-diabetic agents, such as semaglutide and dulaglutide (SURPASS-2) (SURPASS J-mono), long-acting insulin analogs (degludec and glargine) (SURPASS-3,4), and placebo (SURPASS-1) (SURPASS-5), in managing T2DM diabetes [65,66,67,68,69]

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Spiller HA, Krenzelok EP, Klein-Schwartz W, Winter ML, Weber JA, Sollee DR, et al

Body weight and adiposity models: In diet-induced obesity (DIO) mouse models, retatrutide demonstrated pronounced effects on body weight trajectories over multi-week observation periods compared with vehicle controls

Histopathology 70: 558-567