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12% reported vomiting, compared to 1.7% of placebo These side effects/adverse events are fairly high when you examine other drugs and is definitely something to consider

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Here, we showed that compared with Control group, the full length and cleaved forms of Caspase-11, Caspase-8, Caspase-3, and GSDME were increased, while H 2 downregulated both the expression and maturation of these pyroptosis signaling proteins (Figure 6)