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Administration of metformin increases the abundance of SCFAs-producing microbiota (described previously, see Chapter 4.3), thereby increasing the production of SCFAs
The STEP 1 trial for semaglutide 2.4mg demonstrated a mean body weight reduction of approximately 14.9% over 68 weeks in adults with obesity. The SURMOUNT-1 trial for tirzepatide showed reductions of up to 22.5% at the highest dose. These are outcomes that approach the efficacy of bariatric surgery in some patient cohorts
Along with the positive effects on glycaemic control, the GLP-1 RAs have other beneficial effects on the cardiovascular system [5, 7], and semaglutide has been shown to reduce cardiovascular outcomes [8]
It brings youthful appearance by improving skin texture, tone, and hydration
doi:10.3390/biom10081181 Schwahn BC, Chen Z, Laryea MD, et al
it can increase certain thyroid hormone levels
