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At minimum, check metabolic panels, liver function, lipid profiles, and fasting glucose before starting and every 8-12 weeks during combination therapy

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Practical Guidance (Interim) Clinicians should counsel that current evidence does not justify routine therapeutic use outside registered ethically approved research protocols and that online sourcing introduces quality, legal and professional risk

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They are for research use onlynot for human or animal consumption

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Inflammatory bowel disease: Conditions like Crohn's disease can increase the risk of fissures

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