Thats why treatment begins at a low dose
Phase IIb study of intranasal glutathione in Parkinson's disease
That came out of animal model studies, where they gave large amounts of these drugs, and the animal model would get what's called C cell hyperplasia
Sermorelin, Ipamorelin 10mg (Blend) $95,00 PRODUCT SHORT DESCRIPTION The Sermorelin and Ipamorelin 10mg Blend is a precision-formulated research compound designed to facilitate the study of dual-mechanism somatotropic signaling
Chin J Integr Med 16:4149 Wu Z, Li Y, Li M, Wang J, Yang M, Chen M (2008)
The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]