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The peptides copper-binding property is central to its biological activity, as the Cu ion participates in many of the compounds observed effects

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Unlike the SUSTAIN-6 study, this study excluded any patients who had pre-existing proliferative diabetic retinopathy (PDR) prior to initiation of tirzepatide and matched patients with their baseline level of DR or DME

doi: 10.1089/chi.2019.0040 Tulipano G (2021): Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area